Journal
EUKARYOTIC CELL
Volume 5, Issue 12, Pages 2184-2188Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.00274-06
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Funding
- NIEHS NIH HHS [P30ES02109, P30 ES002109] Funding Source: Medline
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Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.
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