Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 20, Issue 6, Pages 1319-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2006.09.011
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Funding
- NCI NIH HHS [R01 CA089054-05, R01 CA 107192, R01 CA 89054, R01 CA107192, R01 CA089054] Funding Source: Medline
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The most important contribution to the understanding and management of paraneoplastic neurologic disorders (PND) is the discovery that many of these disorders are immune mediated. It is believed that cytotoxic T-cell responses and antibodies that target neuronal proteins usually expressed by the underlying tumor cause the neurologic symptoms. The detection of these antibodies has provided diagnostic tests that allow recognition of the disorder as paraneoplastic and direct die search of the tumor to selected organs. This article summarizes die authors' findings of limbic encephalitis and postulates that a similar approach can be used for syndromes involving other areas of the nervous system.
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