Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 31, Issue 12, Pages 687-693Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2006.10.007
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Studies of the intracellular localization of mRNA have clearly demonstrated that certain subsets of mRNA are concentrated in discrete locations within the cytoplasm. Localization is one aspect of the post-transcriptional control of gene expression, and is intertwined with the translation and turnover of mRNA to achieve the goal of local protein production. Different mechanisms have been identified that enable localized mRNAs to target different subcellular compartments, and recent advances in understanding these pathways is reviewed here.
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