4.4 Article

Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch

Journal

PEPTIDES
Volume 27, Issue 12, Pages 3208-3215

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2006.08.018

Keywords

neuropeptide y (NPY); NPY receptors; inflammation; granulocytes rat

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We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.

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