Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 181, Issue 1-2, Pages 133-140Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2006.07.014
Keywords
multiple sclerosis; glatiramer acetate; CD8+T cells; IL-4; IL-10; IFN-gamma
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Glatiramer acetate (GA) is an approved drug for therapy of relapsing remitting MS that acts as a T cell antigen. Here, we report the cloning of HLA restricted, GA-specific human CD8+ T cells. In addition, we analyzed the cytokine profile of GA-reactive CD8+ T cell lines. Unexpectedly, IL-4 was increased in untreated NIS patients as compared to healthy individuals (p < 0.001). In GA-treated patients, however, IL-4 (p < 0.001), IL-10 (p < 0.001) and TNF-alpha (p < 0.001) were decreased. Thus, while GA is known to induce a TH2 bias in CD4+ T cells, we detected a distinct pattern in GA-reactive CD8+ T cells. (c) 2006 Elsevier B.V. All rights reserved.
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