Journal
RHEUMATOLOGY
Volume 45, Issue 12, Pages 1461-1465Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kel329
Keywords
Behcet's disease; innate; adaptive; pathogenesis
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Behcet's disease (BD) is a systemic inflammatory disorder with a diverse spectrum of clinical manifestations including mucocutaneous, ocular, vascular, gastrointestinal, musculoskeletal and central nervous system involvement [1]. A complex genetic background leading to a pro-inflammatory, innate-immune-system-derived activation perpetuated by adaptive immune responses against enviromental and auto-antigens is accepted to be the hallmark of BD [2]. This review aims to make an in-depth critical analysis of current data for recent controversies on the role of innate immune system vs autoimmunity in BD [3-5].
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