Journal
DEVELOPMENT
Volume 133, Issue 23, Pages 4613-4617Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02678
Keywords
zebrafish; time-lapse microscopy; neurulation; cyclopia; quantitative analyses
Categories
Funding
- Medical Research Council [G0400709] Funding Source: Medline
- Medical Research Council [G0400709] Funding Source: researchfish
- MRC [G0400709] Funding Source: UKRI
Ask authors/readers for more resources
Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available