Journal
OPHTHALMIC GENETICS
Volume 27, Issue 4, Pages 117-122Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/13816810600976806
Keywords
Rds; peripherin; rds/peripherin-2; rds/peripherin; outer segment; retina
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Funding
- NEI NIH HHS [R01 EY010609] Funding Source: Medline
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The Retinal Degeneration Slow (Rds) protein is required by photoreceptors for proper formation of the specialized outer segment organelle. Human mutations in Rds cause a multitude of blinding diseases such as retinitis pigmentosa and macular degeneration. In recent years, the use of animal models and biochemical approaches has provided evidence towards the precise function of Rds and its role in the pathogenesis of human disease. This review addresses the current understanding of the role of Rds in photoreceptor outer segment morphogenesis and provides insight into the design of therapeutic strategies to treat Rds-associated retinal diseases.
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