Journal
TRANSPLANT IMMUNOLOGY
Volume 17, Issue 1, Pages 58-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.trim.2006.09.017
Keywords
dendritic cells; regulatory T cells; tryptophan
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Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4(+)CD25(-) cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo. (c) 2006 Elsevier B.V. All rights reserved.
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