Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1758, Issue 12, Pages 1885-1892Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2006.08.004
Keywords
ceramide; glycosphingolipid; endoplasmic reticulum; Golgi apparatus; plasma membrane; mitochondria; vesicular transport; CERT
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The intracellular routes of sphingolipid trafficking are related to the compartmentalized nature of sphingolipid metabolism, with synthesis beginning in the endoplasmic reticulum, continuing in the Golgi apparatus, and degradation occurring mainly in lysosomes. Whereas bulk sphingolipid transport between subcellular organelles occurs primarily via vesicle-mediated pathways, evidence is accumulating that sphingolipids are found in subcellular organelles that are not connected to each other by vesicular flow, implying additional trafficking routes. After discussing how sphingolipids are transported through the secretory pathway, I will review evidence for sphingolipid metabolism in organelles such as the mitochondria, and then discuss how this impacts upon our current understanding of the regulation of intracellular sphingolipid transport. (c) 2006 Elsevier B.V. All rights reserved.
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