Journal
ANNALS OF EPIDEMIOLOGY
Volume 16, Issue 12, Pages 908-916Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2006.03.001
Keywords
epidemiology; hormones; menstruation; risk factors; stomach cancer; women
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PURPOSE: The role of menstrual and reproductive risk factors for gastric cancer has not been well studied. METHODS: This population-based case-control study included 326 women aged 20 to 74 years with gastric adenocarcinoma. Controls were 326 women frequency matched on age. Data for reproductive and/or hormonal exposure and gastric cancer risk factors were captured through self-administered questionnaire. RESULTS: Later age at menarche was associated with increased risk for adenocarcinoma compared with menarche onset at younger than 13 years of age (13 to 14 years: odds ratio [OR], 1.45; 95% confidence interval [CI], 1.00-2.10; >= 15 years: OR, 1.93; 95% CI, 1.19-3.13). Compared with premenopause, natural menopause was associated with increased risk for adenocarcinoma (OR, 1.99; 95% Cl, 0.98-4.05). Compared with nulliparity, 4 or more births were associated with decreased risk for gastric cancer, as was being pregnant for 5 months or longer if the first pregnancy occurred at younger than 24 years (OR, 0.55; 95% Cl, 0.31-0.96) or 25 years or older (OR, 0.67; 95% Cl, 0.38-1.18). Oral contraceptives and hormone replacement therapy were associated with a non-statistically significant decreased risk. CONCLUSION: These findings suggest that hormonal factors associated with greater exposure to estrogen and/or progesterone may be associated with decreased risk for gastric cancer. (c) 2006 Elsevier Inc. All rights reserved.
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