Journal
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume 291, Issue 6, Pages L1113-L1117Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00266.2006
Keywords
acute respiratory distress syndrome; mechanical ventilation; single nucleotide polymorphisms; haplotype
Categories
Ask authors/readers for more resources
Genomic insights into acute inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol 291: L1113-L1117, 2006. First published July 28, 2006; doi:10.1152/ajplung. 00266.2006.-Acute lung injury (ALI) is a devastating syndrome ( usually associated with sepsis) that represents a major healthcare burden in the United States. We have focused our studies on unraveling the genetic underpinnings of this syndrome utilizing a candidate gene approach to identify novel genes for ALI susceptibility. Two novel genes identified by this approach include pre-B cell colony-enhancing factor (PBEF) and the gene for myosin light chain kinase (MLCK). PBEF protein levels were elevated in human bronchoalveolar lavage and serum samples from patients with ALI, and DNA sequencing identified two single nucleotide polymorphisms in the PBEF promoter (T-1001G, C-1543T) that were over-represented in patients with sepsis-induced ALI. More recently, we found MLCK single polymorphisms and haplotypes to be associated with human ALI with unique variants observed in African-Americans with ALI. Thus genomic and genetic approaches represent powerful strategies in the identification of novel candidate genes and potential targets for ALI therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available