Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 18, Issue 6, Pages 609-615Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2006.08.015
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Funding
- NCI NIH HHS [CA90917, CA78810] Funding Source: Medline
- NHLBI NIH HHS [HL54131] Funding Source: Medline
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Survivin has aroused keen interest in disparate areas of basic and translational research. This stems from the complexity of a I survivin network', which appears to intersect multiple pathways of cell division, resistance to apoptosis, surveillance checkpoints and adaptation to unfavorable environments. Such intricacy has also engendered different models for survivin function and its implications. As antagonists of survivin are being evaluated in the clinic, a critical reassessment of the pathway, especially with respect to cell division and cell survival, is now a priority. Building a unifying model to reconcile the differing views on survivin will aid in the design and interpretation of molecularly based clinical trials targeting this network in humans.
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