Journal
CEREBRAL CORTEX
Volume 16, Issue 12, Pages 1783-1789Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhj113
Keywords
Brodmann's area 10; fMRI; frontal pole; meta-analysis; PET; response time
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Funding
- Wellcome Trust Funding Source: Medline
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We analyzed the behavioral data from 104 neuroimaging studies using positron. emission tomography or functional magnetic resonance imaging that reported activation peaks in rostral prefrontal Cortex (PFC), approximating Brodmann's area 10. The distribution of absolute x coordinates of activation peaks (i.e., x coordinate regardless of hemisphere) differed significantly from a unimodal normal distribution, reflecting distinct clusters of activation in lateral and medial subregions. These 2 clusters were associated with different patterns of behavioral data. Lateral activations were associated with contrasts between experimental and control conditions where response times (RTs) were slower in the experimental condition. Medial activations were associated with contrasts where RTs were, if anything, faster in experimental than control conditions. These findings place important constraints on theories of rostral PFC functions.
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