Journal
VISION RESEARCH
Volume 46, Issue 27, Pages 4502-4509Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2006.07.029
Keywords
centrin; transducin; photoreceptors; light-dependent translocation; connecting cilium
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Centrins are members of a highly conserved subgroup of the EF-hand superfamily of Ca2+-binding proteins commonly associated with centrosome-related structures. In the retina, centrins are also prominent components of the photoreceptor cell ciliary apparatus. Centrin isoforms are differentially localized at the basal body and in the lumen of the connecting cilium. All molecular exchanges between the inner and outer segments occur through this narrow connecting cilium. Ca2+-activated centrin isoforms bind to the visual heterotrimeric G-protein transducin via an interaction with the beta gamma-subunit. Ca2+-dependent assemblies of centrin/G-protein complexes may regulate the transducin movement through the connecting cilium. Formation of this complex represents a novel mechanism in regulation of translocation of signaling proteins in sensory cells, as well as a potential link between molecular trafficking and signal transduction in general. (c) 2006 Elsevier Ltd. All rights reserved.
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