Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 12, Pages 932-943Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2058
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Funding
- NIGMS NIH HHS [R37 GM034557] Funding Source: Medline
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Failure to reactivate either stalled or collapsed replication forks is a source of genomic instability in both prokaryotes and eukaryotes. In prokaryotes, dedicated fork repair systems that involve both recombination and replication proteins have been identified genetically and characterized biochemically. Replication conflicts are solved through several pathways, some of which require recombination and some of which operate directly at the stalled fork. Some recent biochemical observations support models of direct fork repair in which the removal of the blocking template lesion is not always required for replication restart.
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