Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 494, Issue 1, Pages 23-30Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2015.07.076
Keywords
Electrospinning; Electroblowing; Spray drying; Raman mapping; Rapid dissolution; Itraconazole
Categories
Funding
- OTKA Research Fund [112644, 108975]
- New Szechenyi Plan [TA'MOP-4.2.1/B-09/1/KMR-2010-0002]
- Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
- Postdoctoral Research Scholarship of the Hungarian Academy of Sciences
- MedInProt project
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Three solvent based methods: spray drying (SD), electrospinning (ES) and air-assisted electrospinning (electroblowing; EB) were used to prepare solid dispersions of itraconazole and Eudragit E. Samples with the same API/polymer ratios were prepared in order to make the three technologies comparable. The structure and morphology of solid dispersions were identified by scanning electron microscopy and solid phase analytical methods such as, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Raman chemical mapping. Moreover, the residual organic solvents of the solid products were determined by static headspace-gas chromatography/mass spectroscopy measurements and the wettability of samples was characterized by contact angle measurement. The pharmaceutical performance of the three dispersion type, evaluated by dissolution tests, proved to be very similar. According to XRPD and DSC analyses, made after the production, all the solid dispersions were free of any API crystal clusters but about 10 wt% drug crystallinity was observed after three months of storage in the case of the SD samples in contrast to the samples produced by ES and EB in which the polymer matrix preserved the API in amorphous state. (C) 2015 Elsevier B.V. All rights reserved.
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