Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 348, Issue 18, Pages 2579-2584Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200600238
Keywords
asymmetric catalysis; ketoimines; organocatalyst; Strecker reaction
Categories
Ask authors/readers for more resources
A novel bifunctional N,N'-dioxide derived from L-prolinamide was employed to catalyze the enantioselective Strecker reaction of a range of N-tosyl ketoimines, and an effective additive was used to improve the reactivity (up to 99% yield) as well as the enantioselectivity (up to 91% ee). In addition, a rational transition state was proposed to elucidate the origin of chiral induction in which an S-adduct was produced.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available