Journal
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
Volume 12, Issue 4, Pages 373-377Publisher
SPRINGER
DOI: 10.1007/s10989-006-9041-4
Keywords
AMLs; Bacillus sp fmbj; Infectious Bursal Disease Virus; Newcastle Disease Virus; Porcine Parvovirus; Pseudorabies Virus
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Bacillus subtilis fmbj can produce lipopeptide antimicrobial substance, whose main components were SUrfactin and fengycin. In the study, the antiviral activity of antimicrobial lipopeptides (AMLs) from B. subtilis fmbj (CGMCC No. 0934) against Pseudorabies Virus (PRV), Porcine Parvovirus (PPV), Newcastle Disease Virus (NDV) and Infectious Bursal Disease Virus (IBDV) was evaluated in vitro. The AMLs represented a direct inactivation effect on cell-free virus stocks of PRV, PPV, NDV and IBDV, and it could effectively inhibit infection and replication of the NDV and IBDV, but failed to affect PRV and PPV. The AMLs were represented higher toxicity for the Porcine Kidney (PK-15) cells (50% cytotoxic concentration (CC50) value was 32.87 mu M) and lower for the Chicken Embryo Fibroblasts (CEF) cells (CC50 value was 89.16 mu M). The Selectivity index of AMLs oil PRV, PPV, NDV and IBDV was 1.44, 2.23, 8.40 and 12.19, respectively.
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