Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 24, Issue 11, Pages 3265-3270Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1460-9568.2006.05195.x
Keywords
amphetamine; blocking; context; fear; rat
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Funding
- Wellcome Trust [063095/Z/00/Z] Funding Source: Medline
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Associative learning depends on the discrepancy between actual and predicted outcomes. The neurochemical mechanisms involved in regulating this discrepancy in Pavlovian fear conditioning in rats are unknown. We employed the blocking paradigm to show that this learning discrepancy is decreased by heightened activation of dopamine following an accumbal infusion Of D-amphetamine, and increased by dopaminegic blockade following an accumbal infusion of cis-(z)-flupenthixol or by combined infusions of the D1 (SCH23390) and D2 (sulpiride) antagonists but not by infusion of either alone.
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