Journal
JOURNAL OF NATURAL PRODUCTS
Volume 69, Issue 12, Pages 1756-1759Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0603828
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Funding
- NCI NIH HHS [CA 44848, CA 66775] Funding Source: Medline
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In the course of our continuing search for new antitumor-antibiotics from marine-derived actinomycete bacteria, four new cytotoxic compounds, designated as daryamides A (1), B ( 2), and C ( 3) and (2E, 4E)-7- methylocta- 2,4-dienoic acid amide (4), were isolated from the culture broth of a marine-derived Streptomyces strain CNQ-085. The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. The relative configuration of 1 was determined by comprehensive NMR analysis, while the absolute configuration of 1 was determined as 4S,5R using the modified Mosher method. The daryamides show weak to moderate cytotoxic activity against the human colon carcinoma cell line HCT-116 and very weak antifungal activities against Candida albicans.
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