Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 12, Pages 4206-4208Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00793-06
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Funding
- NIAID NIH HHS [R37 AI034885, R01 AI034885, AI 34885] Funding Source: Medline
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Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.
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