Journal
AGING CELL
Volume 5, Issue 6, Pages 487-494Publisher
WILEY
DOI: 10.1111/j.1474-9726.2006.00238.x
Keywords
caloric restriction; calorie restriction; dietary restriction; lifespan; stress resistance; worms
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Funding
- NIA NIH HHS [P30 AG013280] Funding Source: Medline
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A partial reduction in food intake has been found to increase lifespan in many different organisms. We report here a new dietary restriction regimen in the nematode Caenorhabditis elegans, based on the standard agar plate lifespan assay, in which adult worms are maintained in the absence of a bacterial food source. These findings represent the first report in any organism of lifespan extension in response to prolonged starvation. Removal of bacterial food increases lifespan to a greater extent than partial reduction of food through a mechanism that is distinct from insulin/IGF-like signaling and the Sir2-family deacetylase, SIR-2.1. Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction.
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