Journal
BRITISH JOURNAL OF SURGERY
Volume 93, Issue 12, Pages 1446-1455Publisher
WILEY
DOI: 10.1002/bjs.5609
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Background: Cancer risk, including pancreatic, is high in those with Peutz-Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer. Methods: The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer. Results: The risk of pancreatic cancer is increased in PJS but screening would cost over US $350000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided. Conclusions: Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups.
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