Journal
CANCER SCIENCE
Volume 97, Issue 12, Pages 1359-1365Publisher
WILEY
DOI: 10.1111/j.1349-7006.2006.00327.x
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We previously reported the identification of natural human IgM antibodies, which recognize a M-r 260 000 surface protein (NB-p260) and induce both complement-mediated cytotoxicity and apoptosis of human neuroblastoma cells. NB-p260 was shown to belong to the family of filamin proteins. Filamin A is a high molecular weight actin-binding protein, previously thought to be only located intracellularly. Here we show that NB cells as well as three NB-unrelated human cell lines express filamin A also on the cell surface. Our findings suggest new biological functions for filamins, including a role as mediators in anti-NB IgM-induced apoptosis, and they add to the growing body of evidence of the interaction of cytoskeletal proteins with the extracellular matrix.
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