Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 44, Issue 12, Pages 4547-4549Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01611-06
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Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.
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