Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 113, Issue 12, Pages 1921-1925Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-006-0484-8
Keywords
Rgs2; chromosome 1q31; panic disorder; linkage disequilibrium; polymorphisms; case-control-study
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Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p=0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p=0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.
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