Journal
CELLULAR SIGNALLING
Volume 18, Issue 12, Pages 2071-2076Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2006.04.007
Keywords
atypical PKC; glucose metabolism; GLUT4; exercise; glycogen synthesis; insulin secretion; cytoskeletal remodeling
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Type 2 diabetes mellitus is a multigenic disease with evident genetic predisposition, and complex pathogenesis in which environmental and genetic factors interact. The disorder of body utilization glucose is a crucial reason for causing diabetes. Atypical PKCs, belonging to Ser/Thr protein kinase, have many important biological functions in vivo, and may be involved in the pathogenesis of diabetes mellitus. APKCs participate in glucose metabolism by regulating glucose transport and absorption, glycogen synthesis, and insulin secretion. The exact mechanism by which aPKCs participate in glucose metabolism remains unclear. So far, the clarification of which will be helpful for the prevention and cure of type 2 diabetes. (c) 2006 Elsevier Inc. All rights reserved.
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