Journal
PHARMACOLOGICAL REVIEWS
Volume 58, Issue 4, Pages 742-759Publisher
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/pr.58.4.6
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Funding
- NCI NIH HHS [CA107011] Funding Source: Medline
- NIDDK NIH HHS [DK62434, DK067158] Funding Source: Medline
- NIEHS NIH HHS [ES012479] Funding Source: Medline
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The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.
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