Journal
SLEEP AND BREATHING
Volume 10, Issue 4, Pages 211-215Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11325-006-0079-5
Keywords
oxidant stress; sleep-disordered breathing; pediatric; isoprostane
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Funding
- NHLBI NIH HHS [F32 HL-074591, HL-65270] Funding Source: Medline
- NIGMS NIH HHS [R37 GM-42056] Funding Source: Medline
- PHS HHS [E11/CCE 422081-01] Funding Source: Medline
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Oxidant stress-related mechanisms have been proposed as a major contributor to the increased prevalence of cardiovascular morbidity in adult patients with sleep-disordered breathing. Isoprostanes provide a reliable biomarker of oxidant injury in vivo. The purpose of the present study was to examine the hypothesis that oxidant stress, as evidenced by increased levels of F-2-isoprostane metabolites ( IsoP-m) in urine, is present in children with a spectrum of sleep-disordered breathing. Assays were performed on urinary samples obtained from each of 47 pediatric patients immediately upon awakening after standard overnight polysomnography. Of the subjects, 15% had mild, 9% had moderate, and 6% had severe sleep-disordered breathing. After controlling for correlations between BMI and IsoP-m and SpO2 values, IsoP-m values were unrelated to any polysomnographic measures. The absence of increased levels of urinary F-2-isoprostane metabolites in children with sleep-disordered breathing suggests that oxidative stress is not a significant feature of pediatric sleep-disordered breathing.
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