Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 54, Issue 12, Pages 1709-1714Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.1709
Keywords
thalidomide; hydroxythalidomide; metabolite; tumor necrosis factor (TNF)-alpha modulator
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Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-alpha production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-alpha production inhibitor than thalidomide.
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