Recurrent genomic imbalances in primary effusion lymphomas

Primary effusion lymphomas (PEL) form a subset of AIDS-related lymphomas and usually have a poor prognosis. Although Kaposi's sarcoma-associated herpes virus (KSHV) is often associated with PEL, very little is known about the exact mechanisms or causative effects of these associations. We investigated the chromosomal imbalances in six KSHV-positive PEL cell lines using comparative genomic hybridization analysis. We defined the shortest regions of overlaps for genomic aains on six chromosomes: 1q31, 4q31 -q33, 7q10-q21, 8q21.1, 12q0 similar to q23, and Xp11 similar to q21. The recurrent nature of the gains found in these chromosomal regions suggests that these imbalances play roles in the pathogenesis of PEL. (c) 2006 Elsevier Inc. All rights reserved.