Journal
FEMS MICROBIOLOGY LETTERS
Volume 265, Issue 1, Pages 126-132Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2006.00481.x
Keywords
Citrobacter rodentium; enteropathogenic Escherichia coli; enterohaemorrhagic E; coli; colonization
Categories
Funding
- Wellcome Trust Funding Source: Medline
Ask authors/readers for more resources
Enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic E. coli (EHEC) and Citrobacter rodentium (CR) colonize the gastrointestinal tract epithelium via attaching and effacing lesions. While humans are believed to be the only living reservoir of typical EPEC and EHEC to have border host specificity, CR is a restricted mouse pathogen. Recently, conflicting conclusions were reported concerning the utility of a murine model to study mechanisms of EPEC and EHEC colonization and infection. We therefore aimed to compare colonization dynamics of EPEC, EHEC and CR, together with a commensal E. coli (Nissle) as a control, in the murine. We show that all strains are equally shed in stools over the first 48 h post inoculation. However, while the CR population then rapidly expanded the EPEC, EHEC and Nissle populations quickly declined to a level just above detection. We conclude that following oral inoculation EPEC and EHEC develop a commensal, rather than pathogenic, interaction within the mouse host.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available