Journal
TRENDS IN CELL BIOLOGY
Volume 16, Issue 12, Pages 607-609Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2006.10.004
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During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.
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