Journal
JOURNAL OF INTERNAL MEDICINE
Volume 260, Issue 6, Pages 509-516Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2796.2006.01726.x
Keywords
endotoxaemia; immunotherapy; infectious disease; inflammation; sepsis
Categories
Ask authors/readers for more resources
The efficacy of intravenous polyclonal immunoglobulin (IVIG) as adjunct therapy in sepsis has long been debated. Clinical trials have yielded contradicting results, in part due to the varying study design and varying microbiological aetiologies. In most trials, the study drug has been IVIG containing polyclonal IgG. However, in recent reports, the efficacy of IgM-enriched IVIG as adjunct therapy in sepsis has been highlighted. Here we review studies on IgM-enriched IVIG therapy in sepsis and we discuss the clinical efficacy in relation to microbiological aetiology and severity of sepsis. The results suggest that patients most likely to benefit from IgM-enriched IVIG therapy are those with Gram-negative septic shock.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available