Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 56, Issue 6, Pages 1200-1210Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21067
Keywords
magnetic resonance; spectroscopic imaging; high field; signal-to-noise ratio; linewidth
Funding
- NCRR NIH HHS [RR08079] Funding Source: Medline
- NIDA NIH HHS [1 R01 DA14178-0] Funding Source: Medline
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This study characterizes gains in sensitivity and spectral resolution of proton echo-planar spectroscopic imaging (PEPSI) with increasing magnetic field strength (B-0). Signal-to-noise ratio (SNR) per unit volume and unit time, and intrinsic linewidth (LW) of N-acetyl-aspartate (NAA), creatine (Cr), and choline (Cho) were measured with PEPSI at 1.5, 3, 4, and 7 Tesla on scanners that shared a similar software and hardware plaff orm, using circularly polarized (CP) and eight-channel phased-array (PA) head coils. Data were corrected for relaxation effects and processed with a time-domain matched filter (MF) adapted to each B-0. The SNR and LW measured with PEPSI were very similar to those measured with conventional point-resolved spectroscopy (PRESS) SI. Measurements with the CP coil demonstrated a nearly linear SNR gain with respect to B-0 in central brain regions. For the PA coil, the SNR-B-0 relationship was less than linear, but there was a substantial SNR increase in comparison to the CP coil. The LW in units of pprn decreased with B-0, resulting in improved spectral resolution. These studies using PEPSI demonstrated linear gains in SNR with respect to B-0, consistent with theoretical expectations, and a decrease in ppm LW with increasingB,.
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