Journal
NEOPLASIA
Volume 8, Issue 12, Pages 1083-U54Publisher
NEOPLASIA PRESS
DOI: 10.1593/neo.06421
Keywords
lymph nodes; prostate cancer; aCGH; metastases; biomarkers
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Funding
- NCI NIH HHS [P50CA89520, P50 CA089520] Funding Source: Medline
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The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the disease process and the development of biomarkers and therapeutic targets. In this study, whole genome copy number changes in genomes of hormone-naive lymph node metastases were profiled using array comparative genomic hybridization, and matched primaries were included for a subset. Matched primaries and lymph node metastases showed very similar copy number profiles that are distinct from primary tumors that fail to metastasize.
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