Journal
FREE RADICAL RESEARCH
Volume 40, Issue 12, Pages 1269-1276Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760600917144
Keywords
protein oxidation; protein maintenance; aging; replicative senescence; proteasome; peptide methionine sulfoxide reductases
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According to the free radical theory of aging proposed by Denham Harman (Journal of Gerontology 1956, 11, pp. 298-300), the continuous oxidative damage to cellular components over an organism's life span is a causal factor of the aging process. The age-related build-up of oxidized protein is therefore resulting from increased protein oxidative damage and/or decreased elimination of oxidized proteins. In this mini-review, we will address the fate, during aging, of the protein maintenance systems that are involved in the degradation of irreversibly oxidized proteins and in the repair of reversible protein oxidative damage with a special focus on the methionine sulfoxide reductases system. Since these protein degradation and repair systems have been found to be impaired with age, it is proposed that not only failure of redox homeostasis but, as importantly, failure of protein maintenance are critical factors in the aging process.
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