Journal
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 16, Issue 12, Pages 1665-1672Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543776.16.12.1665
Keywords
artemisinin; dimers; endoperoxides; trioxanes
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The recent scientific and patent literature on therapeutically promising anticancer trioxanes derived from the antimalarial artemisinin are reviewed through mid-2006. Several of these new chemical entities, especially some trioxane dimers, have selective and very potent anticancer activity even at low nanomolar concentrations. A major opportunity exists for the development of these and related trioxanes into anticancer drug candidates.
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