Journal
LAB ON A CHIP
Volume 6, Issue 12, Pages 1530-1536Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b612684g
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This paper describes the design, fabrication, and characterization of a microfabricated compartmented culture system (mu-CCS) useful for electrophysiological signaling studies in cultured neurons. The focus of the paper is the process of interfacing the mu-CCS with cultured neurons and to demonstrate the applicability of the system for biochemical-mediated electrophysiological studies. Moreover, we show that we can record action potentials from cultured neurons through the extracellular compartmented application of elevated levels of K+ ions. Finally, we show that we can isolate the electrophysiological effects of the sodium channel blocker tetrodotoxin in one of the compartments of a two compartment culture while recording electrophysiological data from both compartments.
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