Journal
INFECTION AND IMMUNITY
Volume 74, Issue 12, Pages 6590-6598Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00868-06
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- NIAID NIH HHS [P01 AI055621, AI 055621] Funding Source: Medline
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The cell composition of early hepatic lesions of experimental murine tularemia has not been characterized with specific markers. The appearance of multiple granulomatous-necrotic lesions in the liver correlates with a marked increase in the levels of serum alanine transferase and lactate dehydrogenase. Francisella tularensis, detected by specific antibodies, can be first noted by day I and becomes associated with the lesions by 5 days postinoculation. These lesions become necrotic, with some evidence of in situ apoptosis. The lesions do not contain B, T, or NK cells. Rather, the lesions are largely composed of two subpopulations of Mac-1(+) cells that are associated with the bacteria. Gr-l(+) Mac-1(+) immature myeloid cells and major histocompatibility complex class H-positive (MHC-II+) Mac-1+ macrophages were the most abundant cell phenotypes found in the granuloma and are likely major contributors in controlling the infection in its early stages. Our findings have shown that there is an early development of hepatic lesions where F. tularensis colocalizes with both Gr-1(+) Mac-1(+) and MHC-II+ Mac-1(+) cells.
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