Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 6, Issue 6, Pages 615-619Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2006.09.002
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- PHS HHS [R0-1 38325] Funding Source: Medline
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Molecular mechanisms involving oxidative stress have been increasingly implicated in the pathogenesis of type 2 diabetes. These implications have arisen from reports that glucolipotoxicity of the pancreatic islet and non-islet tissues can lead to deterioration of islet function and insulin sensitivity, as well as structural abnormalities in tissues adversely affected by diabetes. Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1.
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