Journal
EPILEPSIA
Volume 47, Issue 12, Pages 2183-2185Publisher
WILEY
DOI: 10.1111/j.1528-1167.2006.00711.x
Keywords
parkinsonism; cognitive decline; valproate; epilepsy
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Purpose: We report the frequency of parkinsonism and cognitive decline (P/CD) in patients treated with valproate (VPA) after 1 year of treatment and at least 1 year of follow-up. Methods: Three hundred sixty-four patients with various epileptic syndromes and seizure types were treated with VPA mono- or polytherapy for more than 1 year. Results: We found five cases of P/CD (1.37%; 95% CI, 0.18-2.56%). Among 140 patients with different adverse effects (AEs) of VPA, P/CD were among the rarest in frequency but significant in terms of drug discontinuation (five of 17). Conclusions: Early identification of this type of AE and discontinuation of the drug led to complete recovery in affected patients.
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