Journal
NATURE CELL BIOLOGY
Volume 8, Issue 12, Pages 1313-1316Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1206-1313
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Funding
- NIGMS NIH HHS [R01 GM069957-03, R01 GM069957] Funding Source: Medline
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Regions of metazoan genomes replicate at defined times within S phase. This observation suggests that replication origins fire with a defined timing pattern that remains the same from cycle to cycle. However, an alterative model based on the stochastic firing of origins may also explain replication timing. This model assumes varying origin efficiency instead of a strict origin-timing programme. Here, we discuss the evidence for both models.
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