Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 14, Issue 23, Pages 7846-7853Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.07.059
Keywords
fructose; 1,6-bisphosphatase inhibitors; type 2 diabetes; cyclopenta[b]quinoline derivatives; allosteric inhibitors; anilinequinazolines
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In a search for structurally new inhibitors of fructose-1,6-bisphosphatase (F16BPase), substituted 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives were synthesized. It has been shown that the 2,3-dihydro-IH-cyclopenta[b]quinoline moiety may represent a suitable scaffold for the synthesis of potent F16BPase inhibitors endowed with significantly lower EGFR tyrosine kinase inhibitory activity. (c) 2006 Elsevier Ltd. All rights reserved.
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