Journal
NATURE IMMUNOLOGY
Volume 7, Issue 12, Pages 1237-1242Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1420
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The innate immune system of mammals has been forged by coevolution with microbes in response to the double constraint of preserving a symbiotic interaction with commensal flora and eliminating intrusion of those commensals or invasion by pathogens. Thus, a 'sensing' network, accompanied by or lacking inflammatory responses, is controlled by elaborate mechanisms of regulation that maintain balance in the basal state. A growing number of non-Toll-like innate immune receptors is recognized as part of this surveillance network.
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