Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 44, Issue 12, Pages 4566-4568Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01916-06
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A high rate of double point mutations in gyrA (56% of 87 ofloxacin-resistant Mycobacterium tuberculosis clinical isolates) indicates the emergence of fluoroquinolone resistance. This is the first report to describe denaturing high-pressure liquid chromatography analysis of mutations in gyrA of M. tuberculosis in a large number of clinical isolates.
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