Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 14, Issue 23, Pages 7706-7715Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.08.009
Keywords
dihydrofolate reductase; pyrimidine; triazine; antileishmanial agents
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A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.
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