Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 34, Issue -, Pages 1095-1097Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0341095
Keywords
cannabinoid receptor (CB receptor); central nervous system (CNS); G-protein-coupled receptor (GPCR); middle cerebral artery occlusion; neuroprotection; peroxisome-proliferator-activated receptor (PPAR)
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Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB, (cannabinoid receptor 1). Recently, certain cannabinoids have been reported to be ligands for members of the nuclear receptor transcription factor superfamily known as PPARs (peroxisome-proliferator-activated receptors). This review summarizes the evidence for cannabinoid activation of PPARs and identifies a new intracellular target for cannabinoids as therapeutic agents for neuroprotective treatment.
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