Journal
JOURNAL OF DERMATOLOGY
Volume 33, Issue 12, Pages 887-891Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1346-8138.2006.00203.x
Keywords
discoid lupus erythematosus (DLE); tacrolimus; topical therapy
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Discoid lupus erythematosus (DLE), a cutaneous form of lupus erythematosus, is characterized as atrophic and scaly erythema and the lesions are often refractory to a wide range of topical or systemic therapies. Herein, we present four cases of DLE that were successfully treated with topical tacrolimus. Tacrolimus ointment (0.1%) was applied to DLE lesions twice daily and the erythematous plaques readily diminished after 4-8 weeks. Adverse effects, such as burning sensation or irritations, were not observed. These results indicate that topical tacrolimus might be an effective and alternative treatment to control DLE.
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